Integral field spectroscopy of the radio galaxy 3C 171

We have performed integral field spectroscopy of the radio galaxy 3C 171 (redshift z=0.238) with the TIGER instrument at the Canada France Hawaii telescope in the Hbeta-[OIII]4959-5007 wavelength region. We present the reconstructed Hbeta and [OIII] images and compare them to the HST and radio maps. We discuss the variations of the [OIII]/Hbeta line ratio throughout the nebulosity. We also analyze the velocity field in detail, in particular the presence of several components. We find that the kinematics derived with emission lines in the central region (inside 1 arcsec) are compatible with a disk-like rotation of low amplitude (50 km/s). The continuum surface brightness profile follows an r^{1/4} law, suggesting that the underlying galaxy is an elliptical with an effective radius of 15 kpc. We have fit two components in the region centered 2.7 arcsec to the West and of extension 3 arcsec^2. We find that the blueshifted component is an extension of the central part, whereas the second one is redshifted by 600 km/s. In both components, line ratios and FWHM are compatible with the presence of shocks induced by jet-cloud interactions.Comment: 8 pages, 15 figures. Accepted for publication in A&A Main Journal (July, 3rd

Donde en el mundo estas? (Where in the world are you?)

Grade Level(s): 11-12Students will learn to give & follow directions given in Spanish, using oral, written and graphics.North White HS Monon, I

WHAT OUR HEARTS CRAVE FOR: AN EXAMINATION OF THE PARADOXICAL ATTRACTION TO DANTE’S INFERNO

This paper serves to analyze and explain why audiences are attracted to stories with elements of Horror in them, using Dante’s Inferno as the vehicle for this conversation, as the Inferno’s setting is in the worse possible place imaginable. Horror narratives arise feelings of fear and disgust in its audiences through the use of monsters, as audiences relate to the fear and disgust the positive characters in the narratives are feeling because of the monster’s presence. Since these emotions arise in a safe space, such as in literature or film, where the source of the emotions is not endangering the audiences, the audience is able to safely purge or purify these emotions within them, in a process known as Catharsis. Thus, it is this desire to have these heightened emotions without any of the risks that causes audience members to seek out Horror narratives

Mexica Music

This paper explores the society of Mexica, or the Aztecs, and some of the instruments that were produced in the civilization and used in today’s compositions. The history and their creation mythology will also be deliberated for those individuals who do not know this information of the culture. In the history, the subjects of the Mexica constructing a giant city in a lake to the conquest that was lead by Hernan Cortez will be discussed. The creation story will also exhibit the ideology of the Mexica and how their culture is sustained before the conquest. In the music section, the percussion and wind instruments are listed and described what they are used for in a music piece or other cultural usage. Some of these instruments are also illustrated on how they were created and how musicians play them today. The following will also be describing the importance of these instruments when they are performed in a Mexica ceremonial music piece

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke

<p><b>Background and Purpose:</b> Clinical research into the treatment of acute stroke is complicated, is costly, and has often been unsuccessful. Developments in imaging technology based on computed tomography and magnetic resonance imaging scans offer opportunities for screening experimental therapies during phase II testing so as to deliver only the most promising interventions to phase III. We discuss the design and the appropriate sample size for phase II studies in stroke based on lesion volume.</p> <p><b>Methods:</b> Determination of the relation between analyses of lesion volumes and of neurologic outcomes is illustrated using data from placebo trial patients from the Virtual International Stroke Trials Archive. The size of an effect on lesion volume that would lead to a clinically relevant treatment effect in terms of a measure, such as modified Rankin score (mRS), is found. The sample size to detect that magnitude of effect on lesion volume is then calculated. Simulation is used to evaluate different criteria for proceeding from phase II to phase III.</p> <p><b>Results:</b> The odds ratios for mRS correspond roughly to the square root of odds ratios for lesion volume, implying that for equivalent power specifications, sample sizes based on lesion volumes should be about one fourth of those based on mRS. Relaxation of power requirements, appropriate for phase II, lead to further sample size reductions. For example, a phase III trial comparing a novel treatment with placebo with a total sample size of 1518 patients might be motivated from a phase II trial of 126 patients comparing the same 2 treatment arms.</p> <p><b>Discussion:</b> Definitive phase III trials in stroke should aim to demonstrate significant effects of treatment on clinical outcomes. However, more direct outcomes such as lesion volume can be useful in phase II for determining whether such phase III trials should be undertaken in the first place.</p&gt

The long and viscous road: uncovering nuclear diffusion barriers in closed mitosis.

This is the final version of the article. Available from Public Library of Science via the DOI in this record.Diffusion barriers are effective means for constraining protein lateral exchange in cellular membranes. In Saccharomyces cerevisiae, they have been shown to sustain parental identity through asymmetric segregation of ageing factors during closed mitosis. Even though barriers have been extensively studied in the plasma membrane, their identity and organization within the nucleus remains poorly understood. Based on different lines of experimental evidence, we present a model of the composition and structural organization of a nuclear diffusion barrier during anaphase. By means of spatial stochastic simulations, we propose how specialised lipid domains, protein rings, and morphological changes of the nucleus may coordinate to restrict protein exchange between mother and daughter nuclear lobes. We explore distinct, plausible configurations of these diffusion barriers and offer testable predictions regarding their protein exclusion properties and the diffusion regimes they generate. Our model predicts that, while a specialised lipid domain and an immobile protein ring at the bud neck can compartmentalize the nucleus during early anaphase; a specialised lipid domain spanning the elongated bridge between lobes would be entirely sufficient during late anaphase. Our work shows how complex nuclear diffusion barriers in closed mitosis may arise from simple nanoscale biophysical interactions.OIST funding

Delays induce novel stochastic effects in negative feedback gene circuits

AbstractStochastic models of reaction networks are widely used to depict gene expression dynamics. However, stochastic does not necessarily imply accurate, as subtle assumptions can yield erroneous results, masking key discrete effects. For instance, transcription and translation are not instantaneous processes—explicit delays separate their initiation from the appearance of their functional products. However, delays are often ignored in stochastic, single-gene expression models. By consequence, effects such as delay-induced stochastic oscillations at the single-cell level have remained relatively unexplored. Here, we present a systematic study of periodicity and multimodality in a simple gene circuit with negative feedback, analyzing the influence of negative feedback strength and transcriptional/translational delays on expression dynamics. We demonstrate that an oscillatory regime emerges through a Hopf bifurcation in both deterministic and stochastic frameworks. Of importance, a shift in the stochastic Hopf bifurcation evidences inaccuracies of the deterministic bifurcation analysis. Furthermore, noise fluctuations within stochastic oscillations decrease alongside increasing values of transcriptional delays and within a specific range of negative feedback strengths, whereas a strong feedback is associated with oscillations triggered by bursts. Finally, we demonstrate that explicitly accounting for delays increases the number of accessible states in the multimodal regime, and also introduces features typical of excitable systems

Deposits and bank capital structure

In a model with bankruptcy costs and segmented deposit and equity markets, we endogenize the cost of equity and deposit finance for banks. Despite risk neutrality, equity capital earns a higher expected return than direct investment in risky assets. Banks hold positive capital to reduce bankruptcy costs, but there is a role for capital regulation when deposits are insured. Banks could no longer use capital when they lend to firms instead of investing directly in risky assets. This depends on whether the firms are public and compete with banks for equity capital or are private with exogenous amounts of capital